The Best Lion’s Mane Supplements To Beat Brain Fog
If you follow wellbeing trends and hot topics, it will come as no surprise to learn that 2025 is undoubtedly the year of the functional mushroom. Used for thousands of years in herbal and holistic medicine, mushrooms are touted by many experts for their versatile range of benefits. With so many mushroom species available, though, it can be tricky to separate cordyceps from chagas, let alone understand where to begin.
Vogue’s pick of the best lion’s mane supplements at a glance:
Revive Collagen Revive Collagen Concentration & Clarity
One mushroom that stands out as being particularly highly praised is lion’s mane, and because of its many positive effects on mood, memory and focus, it’s a great place to start. “Lion’s mane is a beautiful white mushroom that looks like a cascade of silk threads,” explains Dr Vijay Murthy, functional medicine doctor and founder of The Murthy Clinic. “It’s long been treasured in Asian medicine for nourishing the brain and nerves, [and is] often called a natural nootropic.” Sarah Power, president of Revive Collagen (EMEA & APAC), goes on to explain that “key claimed benefits to note are improved memory, lifted mood, mental clarity, nerve regeneration and neuroplasticity.”
With that in mind, we’ve collated a list of some of the best lion’s mane supplements to try and answered all your need-to-know questions.
In this article:
Best lion’s mane supplement with collagen: Revive Collagen Concentration & Clarity
Revive Collagen
Revive Collagen Concentration & Clarity
- Why it’s Vogue-approved: If you’re already a fan of the purported benefits of collagen (that’s shinier, stronger hair, skin and nails), then give this newly launched daily dose a go. Alongside high-quality marine collagen, it also contains a dose of lion’s mane and himematsutake mushroom, both known to help improve focus and concentration. Other mushrooms also feature with reishi mushroom on hand to help calming along with ashwagandha. To enhance skin and mind benefits even further, there’s also Irish sea moss and vitamin C.
- Formula: Gel
- Contains: 6,000mg marine collagen per serving, lion’s mane mushroom, ashwagandha root, Irish sea moss, reishi mushroom, chaga mushroom, himematsutake mushroom
- Serving: 14 sachets, one sachet once a day
Best pure lion’s mane supplement: Mother Made Focus
- Why it’s Vogue-approved: If you’re looking for a good dose of lion’s mane and nothing else this is a good bet. Formulated with mushrooms sourced from China and organically grown, this is a pure and potent way to introduce the celebrated mushroom into your daily routine and claim back some calm.
- Formula: Capsules
- Contains: 450mg lion’s mane per serving
- Dosage: 60 capsules, 1-2 capsules daily
Viridian Organic Lion’s Mane Extract
- Why it’s Vogue-approved: Known to help improve focus, reduce stress and calm inflammation, this lion’s mane formula is also great if you suffer from any allergies or intolerances, as it’s certified vegan, gluten-free and dairy-free. What makes it such a potent source is also the way it’s harvested and extracted, a unique process which preserves its bioavailability for enhanced absorption.
- Formula: Capsules
- Contains: 400mg lion’s mane per serving
- Dosage: 30 capsules, 1-2 daily
Best lion’s mane supplement for convenience: DIRTEA Lion’s Mane Powder
DIRTEA Lion’s Mane Powder
- Why it’s Vogue-approved: Anything that helps make a good supplement easier to take is a win, and it doesn’t get easier than this to add to your daily routine. With a hefty dose of lion’s mane in each serving, simply add it to your daily cup of tea or coffee or smoothie and enjoy the mood-boosting, brain-boosting benefits without any hassle.
- Formula: Powder
- Contains: 2000mg lion’s mane per serving
- Dosage: 60g, 2g per serving
Best clinically proven lion’s mane supplement: Hifas Da Terra Mico-Leo
- Why it’s Vogue-approved: The uncompromisingly high standards of all Hifas Da Terra products make this is a great option for anyone who relishes science-backed data and thorough sourcing and traceability. As well as supporting your cognitive function and improving productivity, this high concentration of lion’s mane also supports your gut microbiome, ensuring a healthier environment overall.
- Formula: Capsules
- Contains: 495mg lion’s mane, vitamin C
- Dosage: 70 capsules, 1-2 per day
Best multi-mushroom blend: BetterVits Mushroom Powder
BetterVits Mushroom Powder
- Why it’s Vogue-approved: While lion’s mane is known for its ability to help improve focus and attention, it’s not the only mushroom to have excellent health and wellbeing benefits. To really set you up for a better day, this chocolate flavoured formula also contains cordyceps to enhance energy, reishi mushroom to support your body under stress and chaga mushroom to strengthen your immune system.
- Formula: powder
- Contains: lion’s mane, brahmi, cordyceps sinenis, guarana, ashwagandha, vitamin B5, reishi mushroom, ginseng, chaga mushroom, vitamin c
- Dosage: 30 servings
Best lion’s mane supplement for beginners: VitaWell Lion’s Mane Gummies
VitaWell Lion’s Mane Gummies
- Why it’s Vogue-approved: Want to try lion’s mane but don’t know where to start? Try a tasty raspberry and pomegranate flavour gummy like these from VitaWell. Formulated with a good dose of lion’s mane for clarity and concentration, they also contain pantothenic acid to support normal mental performance, iodine which contributes to the normal functioning of the nervous system and zinc which boosts cognitive function.
- Formula: Gummies
- Contains: lion’s mane, pantothenic acid, iodine, zinc
- Dosage: 60 gummies, 2 a day
Best lion’s mane supplement for brain fog: Mycologic Mind Flow
- Why it’s Vogue-approved: Combining the benefits of lion’s mane with ashwagandha and aronia berry means this is a good option for anyone struggling with brain fog, low focus and lack of productivity. All famed for their help improving memory, mood and concentration, this easy-to-take formula is a brain-boosting powerhouse. Simply drop into your mouth or add to your hot or cold drink.
- Formula: Liquid
- Contains: organic lion’s mane mushroom, organic ariona berries, ashwagandha root cuts
- Dosage: 50ml, 2ml daily
FAQs
What are the benefits of taking lion’s mane?
“People usually notice better focus, a calmer mood and smoother digestion,” says Murthy. It’s one of those mushrooms that seems to make the brain and gut talk more kindly to each other. Recent work from the University of Santiago de Compostela using Hifasda Terra’s Herizumib extract showed it supports nerve growth and gut microbiome balance. Clinical and pre-clinical studies (2018–2023) show improved neuroregeneration, lower inflammation markers (IL-6, TNF-α), and stronger immunity in those taking Hericium erinaceus extracts,” he adds.
Why is lion’s mane so good for brain fog?
According to Mycologic partnered mycologist, David Wrench, “Adaptogens [like lion’s mane] through molecular mechanisms, modulate stress hormone production and regulate the HPA axis, crucial for maintaining homeostasis. By doing so, they alleviate the impact of chronic stress, a common contributor to brain fog. Studies suggest that adaptogens, including lion’s mane mushroom, may exert neuroprotective effects by reducing oxidative stress and inflammation in the brain. [It’s also] noted for stimulating nerve growth factor (NGF), promoting brain health and potentially aiding in cognitive function.”
How is it most frequently used or taken?
“Most people take it as capsules or powder, though newer fermented liquid forms are more absorbable and gentle on the stomach,” advises Murthy. “Hifas da Terra’s Mico-Digest 2.0 nano-emulsion improves bioavailability by over 70 per cent, confirmed in diffusion studies at the University of Santiago de Compostela.”
What’s the optimal amount to take?
Around one to two grams a day of a concentrated extract works well for most, according to Murthy, and it’s best taken daily for a few months rather than occasionally for best results. “Clinical ranges between 1.4–3 g per day have shown benefits in cognitive and immune health trials, such as the 2012 Cochrane Review and subsequent European RCTs,” he adds.
How long before you see results?
“It’s subtle but steady; most people feel clearer and more balanced after three to four weeks, with deeper benefits building over time,” continues Murthy. “In Mico-Digest 2.0 trials, measurable changes in microbiota and inflammation appeared after 12 weeks.”
Can you take too much lion’s mane?
“It’s remarkably safe,” says Murthy. “Even high doses rarely cause anything more than mild bloating in sensitive people.” Power agrees but cautions against taking more than 3g daily to avoid a potentially upset stomach. “But too much of anything could cause issues; best to stick to the standard ranges.”
Anyone who shouldn’t take it?
“Almost everyone can, but those with mushroom allergies or on strong immunosuppressants should be cautious,” explains Murthy. “Otherwise, it’s one of nature’s gentlest allies. Across over 9,000 patients in 135 clinical trials (Zhang et al., 2019), no serious adverse effects were reported for medicinal mushroom extracts.”
Meet the experts
- Dr Vijay Murthy is a functional medicine doctor and the founder of The Murthy Clinic
- Sarah Power is president of Revive Collagen (EMEA & APAC)
- David Wrench is a mycologist who works with adaptogenic mushroom wellbeing brand Mycologic